Consortium PSYCHIATRICUMConsortium PSYCHIATRICUMConsortium PSYCHIATRICUM2712-76722713-2919Eco-Vector1560110.17816/CP15601HISTORICAL PERSPECTIVEИСТОРИЧЕСКАЯ ПЕРСПЕКТИВАResearch ArticleModern concept of depression pathogenesis: the contribution of I.P. Lapin’s research teamВклад работ коллектива И.П. Лапина в становление современной модели патогенеза депрессивных расстройствhttps://orcid.org/0000-0001-5618-420635593613200U-1562-20179772-0024NeznanovNikolay G.НезнановНиколай Григорьевич
Russian Federation

MD, Dr. Sci. (Med.), Professor, Director, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; Head of the Department of Psychiatry and Narcology, Pavlov First State Medical University of Saint Petersburg

spbinstb@bekhterev.ruhttps://orcid.org/0000-0002-3418-859657224679509AAI-7859-20205422-4593TumovaMarianna A.ТумоваМарианна Анатольевна
Russian Federation

Junior Research Associate, Department of Biological Therapy of Mental Disorders

marianna_tumova@mail.ruhttps://orcid.org/0000-0003-1677-0694573474306004407-6915FreizeVictoria V.ФрейзеВиктория Васильевна
Russian Federation

Junior Researcher, Scientific and Organizational Department

v.freize@mail.ruhttps://orcid.org/0000-0002-6317-577857963010300HZJ-0663-20232881-6690GerasimchukEkaterina S.ГерасимчукЕкатерина Сергеевна
Russian Federation

Junior Researcher, The Integrative Pharmaco-psychotherapy of Patients with Mental Disorders Department

katherine.gerasimchuk@mail.ruhttps://orcid.org/0000-0001-9020-327157783231000JFN-4303-20233247-3178RadionovDmitriy S.РадионовДмитрий Сергеевич
Russian Federation

Junior Researcher, Department of Borderline Mental Disorders and Psychotherapy

dumradik@mail.ruhttps://orcid.org/0000-0002-8860-986X57273052100ABM-6184-20222167-4923KhobeyshMaria A.ХобейшМария Александровна
Russian Federation

Junior Researcher, The Integrative Pharmaco-psychotherapy of Patients with Mental Disorders Department

mariakhobeysh@mail.ruhttps://orcid.org/0000-0002-5470-4359572501556005156-9223MalyshkoLarisa V.МалышкоЛариса Владимировна
Russian Federation

Junior Researcher, Scientific and Organizational Department

i@kasyan.ruhttps://orcid.org/0009-0003-8707-09407278-4183AnokhinaMaria V.АнохинаМария Валерьевна
Russian Federation

Junior Researcher, Scientific and Organizational Department

anokhinabekhterev@yandex.ruhttps://orcid.org/0000-0002-9313-543516473593800AGN-3892-20228402-0960PalchikovaEkaterina I.ПальчиковаЕкатерина Игоревна
Russian Federation

Junior Researcher, Department of Geriatric Psychiatry

ofcoursekate@gmail.comhttps://orcid.org/0000-0003-2502-6365571913699877807-4497SorokinMikhail Y.СорокинМихаил Юрьевич
Russian Federation

MD, Cand. Sci. (Med.), Academic Secretary, Senior Researcher, The Integrative Pharmaco-psychotherapy of Patients with Mental Disorders Department

m.sorokin@list.ruV.M. Bekhterev National Medical Research Centre for Psychiatry and NeurologyФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава РоссииPavlov First State Medical University of Saint PetersburgФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Минздрава России03072025060720256277840812202429052025Copyright ©; 2025, Neznanov N.G., Tumova M.A., Freize V.V., Gerasimchuk E.S., Radionov D.S., Khobeysh M.A., Malyshko L.V., Anokhina M.V., Palchikova E.I., Sorokin M.Y.Copyright ©; 2025, Незнанов Н.Г., Тумова М.А., Фрейзе В.В., Герасимчук Е.С., Радионов Д.С., Хобейш М.А., Малышко Л.В., Анохина М.В., Пальчикова Е.И., Сорокин М.Ю.2025Neznanov N.G., Tumova M.A., Freize V.V., Gerasimchuk E.S., Radionov D.S., Khobeysh M.A., Malyshko L.V., Anokhina M.V., Palchikova E.I., Sorokin M.Y.Незнанов Н.Г., Тумова М.А., Фрейзе В.В., Герасимчук Е.С., Радионов Д.С., Хобейш М.А., Малышко Л.В., Анохина М.В., Пальчикова Е.И., Сорокин М.Ю.https://creativecommons.org/licenses/by-nc-nd/4.0https://consortium-psy.com/jour/article/view/15601

BACKGROUND: The advent of neuroleptics and antidepressant therapy marked a significant step forward in clinical psychiatry. Numerous experiments worldwide had been dedicated to a search for the potential neurobiological mechanisms underlying the potency of new psychopharmacological drugs. The first laboratory of psychopharmacology in the USSR was established in 1960 at the Leningrad Psychoneurological Institute. It was headed by Professor Izyaslav Petrovich Lapin. The foundational article by Lapin I.P. and Oksenkrug G.F. (The Lancet, 1969) continues to be cited 55 years after its publication, which determines the interest in the role of this research team in shaping temporal concepts of the pathogenesis of depression and the development of psychopharmacology.

AIM: To analyze the contribution of Lapin I.P. and his research team to the development of experimental approaches for studying the mechanisms of depression.

METHODS: We analyzed the articles and monographs authored by Professor Lapin I.P., both individually and in co-authorship, available in PubMed, Google Scholar, eLIBRARY.RU, and in the bibliographic collection of the V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology.

RESULTS: This analysis highlights the significance of Lapin I.P. and his scientific team’s work in advancing our understanding of serotonin role in the mechanisms of depression and in the development of animal depression models. The scientific contribution of this team is an important milestone towards future research into the neurobiological mechanisms underlying depression, as well as the development of therapeutic approaches.

CONCLUSION: Lapin’s scientific publications and the work of his team in the field of psychopharmacology have had a significant impact on the development of neuroscience and continue to be of unquestionable importance in advancing scientific practice more than 50 years later.

ВВЕДЕНИЕ: Появление нейролептиков и антидепрессивной терапии стало существенным шагом вперед в развитии клинической психиатрии. Поиску возможных нейробиологических механизмов, лежащих в основе действия новых психофармакологических препаратов, были посвящены многочисленные эксперименты во всем мире. В 1960 г. в Ленинградском психоневрологическом институте была создана первая в СССР лаборатория психофармакологии, которую возглавил профессор Изяслав Петрович Лапин. Фундаментальную статью И.П. Лапина и Г.Ф. Оксенкруга (The Lancet, 1969) продолжают цитировать спустя 55 лет после публикации, что определяет интерес к роли этого научного коллектива в формировании временных представлений о патогенезе депрессии и развитии психофармакологии.

ЦЕЛЬ: Проанализировать вклад И.П. Лапина и его научного коллектива в разработку экспериментальных подходов к исследованию механизмов развития депрессии.

МЕТОДЫ: Авторы проанализировали статьи и монографии, написанные профессором И.П. Лапиным как индивидуально, так и в соавторстве, доступные в базах данных PubMed, Google Scholar, eLIBRARY.RU и в библиографическом фонде ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России.

РЕЗУЛЬТАТЫ: Проведенный анализ подчеркивает значимость работы И.П. Лапина и его коллег в углублении понимания роли серотонина в механизмах депрессии и в разработке моделей депрессии на животных. Научное наследие этого коллектива является важной вехой на пути к будущим исследованиям нейробиологических механизмов, лежащих в основе депрессии, а также разработке терапевтических подходов.

ЗАКЛЮЧЕНИЕ: Научные публикации И.П. Лапина и работа его коллектива в области психофармакологии оказали существенное влияние на развитие нейронауки и сохраняют свою значимость для передовых научных исследований уже более 50 лет.

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