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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consortium PSYCHIATRICUM</journal-id><journal-title-group><journal-title xml:lang="en">Consortium PSYCHIATRICUM</journal-title><trans-title-group xml:lang="ru"><trans-title>Consortium PSYCHIATRICUM</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2712-7672</issn><issn publication-format="electronic">2713-2919</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">15635</article-id><article-id pub-id-type="doi">10.17816/CP15635</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CASE REPORT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Revisiting delirious mania in the context of neurosyphilis: a case report</article-title><trans-title-group xml:lang="ru"><trans-title>Делириозная мания при нейросифилисе: клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6491-2461</contrib-id><name-alternatives><name xml:lang="en"><surname>Hirsch</surname><given-names>Daniele</given-names></name><name xml:lang="ru"><surname>Хирш</surname><given-names>Даниэле</given-names></name></name-alternatives><address><country country="IT">Italy</country></address><bio xml:lang="en"><p>MD, Consultant Psychiatrist, Department of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care</p></bio><email>daniele.hirsch@aslroma5.it</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-9392-8083</contrib-id><name-alternatives><name xml:lang="en"><surname>Leone</surname><given-names>Beniamino</given-names></name><name xml:lang="ru"><surname>Леоне</surname><given-names>Бениамино</given-names></name></name-alternatives><address><country country="IT">Italy</country></address><bio xml:lang="en"><p>Consultant Psychiatrist, Department of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care</p></bio><email>daniele.hirsch@aslroma5.it</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6281-5561</contrib-id><name-alternatives><name xml:lang="en"><surname>Bernabei</surname><given-names>Laura</given-names></name><name xml:lang="ru"><surname>Бернабей</surname><given-names>Лаура</given-names></name></name-alternatives><address><country country="IT">Italy</country></address><bio xml:lang="en"><p>Psy.D., PhD, Senior Psychologist, Department of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care, The Local Health Authority Rome 5 (ASL Roma 5); Lecturer in Clinical Psychology, Department of Public Health and Infectious Diseases, Sapienza University of Rome</p></bio><email>daniele.hirsch@aslroma5.it</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9377-6881</contrib-id><name-alternatives><name xml:lang="en"><surname>Nicolò</surname><given-names>Giuseppe</given-names></name><name xml:lang="ru"><surname>Николо</surname><given-names>Джузеппе</given-names></name></name-alternatives><address><country country="IT">Italy</country></address><bio xml:lang="en"><p>Director, Department of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care</p></bio><email>daniele.hirsch@aslroma5.it</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">The Local Health Authority Rome 5 (ASL Roma 5)</institution></aff><aff><institution xml:lang="ru">Территориальная служба здравоохранения (ASL Roma 5)</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Sapienza University of Rome</institution></aff><aff><institution xml:lang="ru">Римский университет Ла Сапиенца</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-07-29" publication-format="electronic"><day>29</day><month>07</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-09-26" publication-format="electronic"><day>26</day><month>09</month><year>2025</year></pub-date><volume>6</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>71</fpage><lpage>77</lpage><history><date date-type="received" iso-8601-date="2025-02-16"><day>16</day><month>02</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-07-29"><day>29</day><month>07</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Hirsch D., Leone B., Bernabei L., Nicolò G.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Хирш Д., Леоне Б., Бернабей Л., Николо Д.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Hirsch D., Leone B., Bernabei L., Nicolò G.</copyright-holder><copyright-holder xml:lang="ru">Хирш Д., Леоне Б., Бернабей Л., Николо Д.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consortium-psy.com/jour/article/view/15635">https://consortium-psy.com/jour/article/view/15635</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND: </bold>Delirious mania (DM) is a severe neuropsychiatric syndrome characterized by the acute onset of delirium, psychosis and increased psychomotor activity. Its classification remains debated, with overlapping features of mania, catatonia, and delirium complicating diagnosis and treatment. The condition poses significant challenges in differential diagnosis, particularly in patients with comorbid medical conditions.</p> <p><bold>CASE PRESENTATION: </bold>We report the case of a 52-year-old man with bipolar disorder who presented with acute agitation, disorientation, confabulation, incontinence, and severe behavioral disturbances, initially suggestive of DM. Despite targeted psychiatric treatment, his condition remained refractory until a syphilitic infection was identified, with a possible presentation of neurosyphilis, and treated with antibiotic therapy. Resolution of his symptoms followed, with the delirium persisting briefly after the mania had subsided, suggesting an organic contribution to his presentation.</p> <p><bold>CONCLUSION: </bold>This case highlights the importance of considering organic etiologies, such as neurosyphilis, in presentations of DM. It also supports the view that DM may represent a syndromic entity with both psychiatric and medical underpinnings, rather than merely a subtype of bipolar disorder. Early identification and treatment of DM, along with any underlying medical conditions, are crucial for patient recovery.</p></abstract><trans-abstract xml:lang="ru"><p><bold>ВВЕДЕНИЕ:</bold> Делириозная мания (ДМ) — это тяжелый нейропсихиатрический синдром, характеризующийся острым возникновением делирия, психоза и повышенной психомоторной активности. Классификация заболевания остается предметом дискуссий, поскольку наличие симптомов — мании, кататонии и делирия, — присущих нескольким синдромам, усложняет его диагностику и лечение. Также это создает существенные трудности при дифференциальной диагностике, особенно у пациентов с сопутствующими заболеваниями.</p> <p><bold>ОПИСАНИЕ КЛИНИЧЕСКОГО СЛУЧАЯ: </bold>В представленном клиническом случае у мужчины 52 лет с биполярным расстройством наблюдались острая ажитация, дезориентация, конфабуляция, недержание мочи и выраженные поведенческие нарушения, первоначально трактовавшиеся как проявления ДМ. Несмотря на целевую психиатрическую помощь, состояние пациента оставалось рефрактерным вплоть до выявления сифилитической инфекции с возможной манифестацией нейросифилиса. После проведения антибактериальной терапии последовало разрешение симптомов. При этом после исчезновения мании кратковременно сохранялся делирий, что указывает на органическую природу заболевания.</p> <p><bold>ЗАКЛЮЧЕНИЕ: </bold>Данный клинический случай подчеркивает важность исключения органических причин (в частности, нейросифилиса) при диагностике ДМ. Кроме того, он подтверждает концепцию, согласно которой</p> <p>ДМ не просто является подтипом биполярного расстройства, а может представлять собой синдромальную категорию, имеющую как психическую, так и соматическую основу. Раннее выявление и лечение ДМ, равно как и заболеваний, лежащих в ее основе, играют решающую роль в восстановлении пациента.</p></trans-abstract><kwd-group xml:lang="en"><kwd>delirious mania</kwd><kwd>bipolar disorder</kwd><kwd>catatonia</kwd><kwd>neurosyphilis</kwd><kwd>electroconvulsive therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>делириозная мания</kwd><kwd>биполярное расстройство</kwd><kwd>кататония</kwd><kwd>нейросифилис</kwd><kwd>электросудорожная терапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Fink M. Delirious mania. Bipolar Disord. 1999;1(1):54–60. doi: 10.1034/j.1399-5618.1999.10112.x</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Vyas CM, Petriceks AH, Paudel S, et al. Acute psychosis: differential diagnosis, evaluation, and management. 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