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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consortium PSYCHIATRICUM</journal-id><journal-title-group><journal-title xml:lang="en">Consortium PSYCHIATRICUM</journal-title><trans-title-group xml:lang="ru"><trans-title>Consortium PSYCHIATRICUM</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2712-7672</issn><issn publication-format="electronic">2713-2919</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">85</article-id><article-id pub-id-type="doi">10.17816/CP85</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>RESEARCH</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical Features of First-episode Psychoses During the COVID-19 Pandemic</article-title><trans-title-group xml:lang="ru"><trans-title>Клиническая картина манифестных психотических состояний в период пандемии COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6986-1250</contrib-id><contrib-id contrib-id-type="spin">1584-8386</contrib-id><name-alternatives><name xml:lang="en"><surname>Zyablov</surname><given-names>Vladimir A.</given-names></name><name xml:lang="ru"><surname>Зяблов</surname><given-names>Владимир Андреевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>psychiatrist, Early psychosis unit</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, врач-психиатр Клиники первого психотического эпизода</p></bio><email>v.zyablov@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7577-0884</contrib-id><contrib-id contrib-id-type="spin">7579-3857</contrib-id><name-alternatives><name xml:lang="en"><surname>Gusev</surname><given-names>Mikhail A.</given-names></name><name xml:lang="ru"><surname>Гусев</surname><given-names>Михаил Андреевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>врач-психиатр Клиники первого психотического эпизода</p></bio><email>powilenski@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9885-6664</contrib-id><contrib-id contrib-id-type="spin">6798-4534</contrib-id><name-alternatives><name xml:lang="en"><surname>Chizhikov</surname><given-names>Vasilyi S.</given-names></name><name xml:lang="ru"><surname>Чижиков</surname><given-names>Василий Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>врач-психиатр Клиники первого психотического эпизода</p></bio><email>dr.chigikov@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Mental health clinic No.1 named after N.A. Alexeev</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Психиатрическая клиническая больница №1 им. Н. А. Алексеева Департамента здравоохранения города Москвы»</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2021-09-30" publication-format="electronic"><day>30</day><month>09</month><year>2021</year></pub-date><pub-date date-type="pub" iso-8601-date="2021-11-05" publication-format="electronic"><day>05</day><month>11</month><year>2021</year></pub-date><volume>2</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>27</fpage><lpage>33</lpage><history><date date-type="received" iso-8601-date="2021-06-28"><day>28</day><month>06</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-08-25"><day>25</day><month>08</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Zyablov V.A., Gusev M.A., Chizhikov V.S.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Зяблов В.А., Гусев М.А., Чижиков В.С.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Zyablov V.A., Gusev M.A., Chizhikov V.S.</copyright-holder><copyright-holder xml:lang="ru">Зяблов В.А., Гусев М.А., Чижиков В.С.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consortium-psy.com/jour/article/view/85">https://consortium-psy.com/jour/article/view/85</self-uri><abstract xml:lang="en"><p><bold>INTRODUCTION:</bold> The pandemic of the new coronavirus infection has become one of the most significant global social shocks in the past decade. It influenced the lifestyle of many people, including those with mental disorders.</p> <p><bold>AIM:</bold> To compare the psychopathological structure of psychotic states in young patients (up to 40 years old) with first-episode psychosis before the COVID-19 pandemic and during the COVID-19 pandemic.</p> <p><bold>METHODS:</bold> The research was conducted at the First psychotic episode clinic of the Mental-health clinic No. 1 n.a. N.A. Alexeev, Moscow, Russia. In total, 66 patients were enrolled, who met the inclusion criteria: first-in-life admission to a mental healthcare unit that occurred during the spring of 2019 (control group) or spring 2020 (experimental group), diagnosis on admission that belonged to the group “Acute and transient psychotic disorders” (F23.XX) of ICD-10. Patients with a disability or concurrent somatic or neurologic conditions were excluded from the study. Assessment of clinical and psychopathological characteristics with the allocation of the leading syndrome within the psychotic state, psychometric assessment according to the PANSS scale was carried out, the above indicators were compared between the experimental and control group.</p> <p><bold>RESULTS: </bold>We observed statistically insignificant increase in the rates of affective and catatonic subtypes of psychoses, a decrease in the rate of the delusional subtype of paranoid syndrome. PANSS scores differed significantly for different clinical subtypes of psychoses, although the differences between the experimental and control groups showed no statistical significance. Additionally, in spring 2020, a considerable decrease in the total number of hospitalizations was revealed.</p> <p><bold>CONCLUSIONS:</bold> The differences in the clinical and psychopathological structure of psychotic states revealed during the COVID-19 pandemic were statistically insignificant. Additional results of the study may indicate a decrease in the availability of mental healthcare for patients with psychoses, which requires further investigation.</p></abstract><trans-abstract xml:lang="ru"><p><bold>АКТУАЛЬНОСТЬ: </bold>Пандемия новой коронавирусной инфекции стала одним из социально значимых потрясений всемирного масштаба в последнее десятилетие. Она оказала существенное влияние на уклад жизни многих людей, в том числе на больных с психическими расстройствами.</p> <p><bold>ЦЕЛЬ: </bold>Сравнить психопатологическую структуру манифестных психотических состояний у пациентов молодого возраста (до 40 лет) до пандемии COVID-19 и во время пандемии COVID-19.</p> <p><bold>МАТЕРИАЛ И МЕТОДЫ:</bold> Работа выполнена в клинике первого психотического эпизода, подразделении ГБУЗ «ПКБ №1 им. Н.А. Алексеева» ДЗМ. Всего в исследование включены 66 пациентов, отвечавших критериям включения — первичная госпитализация в ПКБ№1 весной 2019 (группа сравнения — 45 пациентов) или 2020 (основная группа — 21 пациент) года, диагноз из рубрики F23, отсутствие инвалидности, сопутствующей соматической или неврологической патологии, которая затрудняла обследование или требовала дополнительных лекарственных назначений. Проведена оценка клинико-психопатологических характеристик с выделением ведущего синдрома в рамках психотического состояния, психометрическая оценка по шкале PANSS, вышеуказанные показатели сопоставлены между основной группой и группой сравнения.</p> <p><bold>РЕЗУЛЬТАТЫ:</bold> Выявлено статистически незначимое увеличение доли аффективно-бредовых и кататоно-бредовых состояний, а также уменьшение доли параноидных состояний за счет бредового их варианта. Результаты психометрической оценки по PANSS достоверно различались между пациентами с разными клинико-психопатологическими вариантами психозов, однако значимых различий между основной группой и группой сравнения обнаружено не было. Дополнительно было обнаружено уменьшение общего количества госпитализаций весной 2020 года.</p> <p><bold>ВЫВОДЫ: </bold>Выявленные в ходе исследования различия клинико-психопатологической структуры манифестных психотических состояний в период пандемии COVID-19 не продемонстрировали статистической значимости. Побочные результаты исследования могут указывать на изменение доступности психиатрической помощи для пациентов с манифестными психотическими состояниями, что требует дальнейшего изучения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>psychosis</kwd><kwd>first-episode psychosis</kwd><kwd>acute and transient psychotic disorders</kwd><kwd>PANSS</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>психоз</kwd><kwd>первый психотический эпизод</kwd><kwd>острые и преходящие психотические расстройства</kwd><kwd>PANSS</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Gaebel W, Lukies R, Stricker J. COVID-19: сonsequences for mental health and the use of e-Mental health options. Consortium Psychiatricum. 2020;1(1):3-7. doi:10.17650/2712-7672-2020-1-1-3-7</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Karpenko OA, Syunyakov TS, Kulygina MA, et al. Impact of COVID-19 pandemic on anxiety, depression and distress – online survey results amid the pandemic in Russia. Consortium Psychiatricum. 2020;1(1):8-20. doi:10.17650/2712-7672-2020-1-1-8-20</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Filgueiras A, Stults-Kolehmainen M. Risk Factors for Potential Mental Illness Among Brazilians in Quarantine Due To COVID-19. Psychol Rep. 2021:33294120976628. doi:10.1177/0033294120976628</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Luo X, Estill J, Wang Q, et al. The psychological impact of quarantine on coronavirus disease 2019 (COVID-19). Psychiatry Res. 2020;291:113193. doi:10.1016/j.psychres.2020.113193</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Torales J, Rios-Gonzalez C, Barrios I, et al. Self-Perceived Stress During the Quarantine of COVID-19 Pandemic in Paraguay: An Exploratory Survey. Front Psychiatry. 2020;11:558691. doi:10.3389/fpsyt.2020.558691</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet. 2020;395(10227):912-920. doi:10.1016/s0140-6736(20)30460-8</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Pandey D, Bansal S, Goyal S, et al. Psychological impact of mass quarantine on population during pandemics-The COVID-19 Lock-Down (COLD) study. PLoS One. 2020;15(10):e0240501. doi:10.1371/journal.pone.0240501</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Tucker P, Czapla CS. Post-COVID stress disorder: another emerging consequence of the global pandemic. Psychiatric Times. 2021;(38)1.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Yang Y, Li W, Zhang Q, et al. Mental health services for older adults in China during the COVID-19 outbreak. Lancet Psychiatry. 2020;7(4):e19. doi:10.1016/s2215-0366(20)30079-1</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Yao H, Chen J-H, Xu Y-F. Patients with mental health disorders in the COVID-19 epidemic. The Lancet Psychiatry. 2020;7(4):e21. doi:10.1016/s2215-0366(20)30090-0</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Fischer M, Coogan AN, Faltraco F, Thome J. COVID-19 paranoia in a patient suffering from schizophrenic psychosis - a case report. Psychiatry Res. 2020;288:113001. doi:10.1016/j.psychres.2020.113001</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Gouse BM, Spears WE, Nieves Archibald A, Montalvo C. Catatonia in a hospitalized patient with COVID-19 and proposed immune-mediated mechanism. Brain Behav Immun. 2020;89:529-530. doi:10.1016/j.bbi.2020.08.007</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Neznanov NG, Shmukler AB, Kostyuk GP, Sofronov AG. The first psychotic episode: epidemiological aspects of care provision. Article in Russian. Sotsial’naya i klinicheskaya psikhiatriya. 2018;28(3):5-11.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Correa-Palacio AF, Hernandez-Huerta D, Gomez-Arnau J, Loeck C, Caballero I. Affective psychosis after COVID-19 infection in a previously healthy patient: a case report. Psychiatry Res. 2020;290:113115. doi:10.1016/j.psychres.2020.113115</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Smith CM, Komisar JR, Mourad A, Kincaid BR. COVID-19-associated brief psychotic disorder. BMJ Case Rep. 2020;13(8). doi:10.1136/bcr-2020-236940</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Parra A, Juanes A, Losada CP, et al. Psychotic symptoms in COVID-19 patients. A retrospective descriptive study. Psychiatry Res. 2020;291:113254. doi:10.1016/j.psychres.2020.113254</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Huarcaya-Victoria J, Herrera D, Castillo C. Psychosis in a patient with anxiety related to COVID-19: A case report. Psychiatry Res. 2020;289:113052. doi:10.1016/j.psychres.2020.113052</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>vRentero D, Juanes A, Losada CP, et al. New-onset psychosis in COVID-19 pandemic: a case series in Madrid. Psychiatry Res. 2020;290:113097. doi:10.1016/j.psychres.2020.113097</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Cooper JJ, Ross DA. COVID-19 Catatonia-Would We Even Know? Biol Psychiatry. 2020;88(5):e19-e21. doi:10.1016/j.biopsych.2020.07.001</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Caan MP, Lim CT, Howard M. A Case of Catatonia in a Man With COVID-19. Psychosomatics. 2020;61(5):556-560. doi:10.1016/j.psym.2020.05.021</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Zain SM, Muthukanagaraj P, Rahman N. Excited Catatonia - A Delayed Neuropsychiatric Complication of COVID-19 Infection. Cureus. 2021;13(3):e13891. doi:10.7759/cureus.13891</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Sarli G, Polidori L, Lester D, Pompili M. COVID-19 related lockdown: a trigger from the pre-melancholic phase to catatonia and depression, a case report of a 59 year-old man. BMC Psychiatry. 2020;20(1):558. doi:10.1186/s12888-020-02978-2</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Lynch A, Bastiampillai T. COVID-19 Pandemic-Induced Late-Onset Psychotic Depression With Catatonia. Prim Care Companion CNS Disord. 2021;23(1). doi:10.4088/PCC.20l02827</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Ostrovskii DI, Ivanova TI. (2020). Influence of the new coronavirus COVID-19 infection on human mental health (literature review). Article in Russian. Omskii psikhiatricheskii zhurnal. 2020;S2-1(24). doi:10.24411/2412-8805-2020-10201</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Sorokin M, Kasyanov ED, Rukavishnikov GV, et al. Structure of anxiety associated with СOVID-19 pandemic: the online survey results. Bulletin of Russian State Medical University. 2020((3)2020):70-76. doi:10.24075/brsmu.2020.030</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Gritsenko VV, Reznik AD, Konstantinov VV, et al. Fear of Сoronavirus Disease (COVID-19) and Basic Personality Beliefs. Clinical Psychology and Special Education. 2020;9(2):99-118. doi:10.17759/cpse.2020090205</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Mosolov SN. Влияние новой коронавирусной инфекции COVID-19 на психическое здоровье человека (обзор литературы). Novyi tsvet; 2001.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Kay SR, Sevy S. Pyramidical Model of Schizophrenia. Schizophrenia Bulletin. 1990;16(3):537-545. doi:10.1093/schbul/16.3.537</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Zhilyaeva TV, Sergeeva AV, Blagonravova AS, Akimova EV, Kasimova LN. Folate metabolism genetic polymorphism MTHFR 677C&gt;T and catatonic symptoms of schizophrenia. Article in Russian. Nevrologicheskii vestnik, 2016;48:2-S:12-6. doi: 10.17816/nb13977</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Trushchelev SA. General issues of statistical analysis methodology: data types and algorithms selection tables, graphical visualizations. Article in Russian. Russian Journal of Psychiatry. 2014;(1):68-73.</mixed-citation></ref></ref-list></back></article>
