Vol 5, No 4 (2024)
- Year: 2024
- Published: 29.12.2024
- Articles: 6
- URL: https://consortium-psy.com/jour/issue/view/19
- DOI: https://doi.org/10.17816/CP.202454
Full Issue
RESEARCH
Prevalence of Anxiety and Depressive Disorders in a Sample of Moscow Residents: Comparison of the GAD-7 and HADS Results with a Clinical Assessment
Abstract
BACKGROUND: Anxiety and depressive disorders are the most common mental disorders. Detecting a disorder at an early stage can prevent the development of severe disorders and preserve the patient’s functioning ability. Simple and reliable screening tools based on self-completion of questionnaires can be used for this purpose. However, it is not always the case that the scores of the self-questionnaire align with those of the clinician.
AIM: To estimate the prevalence of anxiety-depressive disorders using the GAD-7 and HADS self-report questionnaires compared to psychiatrist assessment.
METHODS: The study included individuals aged 18 to 65 years, living in Moscow, Russia, without psychiatric disorders, who participated in an online study using the HADS (Hospital Anxiety and Depression Scale, HADS-A and HADS-D) and GAD-7 (Generalized Anxiety Disorder 7-item scale). Anxiety disorder was diagnosed when the total score was ≥10 on the GAD-7 and/or ≥10 on the HADS-A scale, and depression was defined when the total score was ≥9 on the HADS-D scale. Then, 82 randomly selected participants attended an anonymous consultation with a psychiatrist.
RESULTS: The study included 1,097 individuals (72% female), median age 29 (23; 37) years. As a result of testing, anxiety disorder was found in 168 (15%); depressive disorder — in 152 (14%) respondents. At medical verification, anxiety was diagnosed in 18 (22%); depression — in 19 (23%) people. The sensitivity of the HADS-D subscale for physician-diagnosed cases of depression was 61%, and specificity was 73%. The sensitivity of the HADS-A and GTR-7 subscale in identifying cases of anxiety disorder was 58%, specificity 59%. Sixteen percent were first diagnosed with a personality disorder or schizotypal disorder.
CONCLUSION: The level of anxiety and depression in our sample of the population of Moscow, Russia, was higher than the global level. Self-assessment based on the questionnaire seems to not fully reflect the real state of a patient, as evidenced by the differences with the psychiatrist’s assessment.
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Dynamics of Clinical Manifestations and Social Functioning in Schizophrenia: A Non-interventional Observational Study of Paliperidone Palmitat Dosage Forms
Abstract
BACKGROUND: Over the past seven years, the use of long-acting forms of antipsychotic medication has significantly increased in Russia. Specifically, in Moscow, from 2016 to 2021, the proportion of prescribed injectable long-acting antipsychotics had increased more than sevenfold (from 3% to 23%). Studies have shown that the correct selection of target groups for such therapy can reduce the frequency of relapses requiring hospitalization, lower the costs of inpatient care, and shift the focus of therapy from multiple drug administrations to psychosocial work.
AIM: This study was aimed at evaluating changes over time in psychosocial functioning, as well as clinical and psychopathological manifestations, in patients with schizophrenia during early remission and while on therapy with different forms of paliperidone: oral paliperidone (OP), paliperidone palmitate administered once monthly (PP1M), and paliperidone palmitate administered once every three months (PP3M).
METHODS: The observational study included 155 patients: 54 patients who had been treated with another second-generation antipsychotic received OP, 50 patients who had been treated with another antipsychotic received PP1M injections, and 51 patients who had been in remission for four months after treatment with PP1M received PP3M. The duration of the follow-up period was 12 months. Assessment of personal and social functioning was conducted five times: before the start of treatment, and 3, 6, 9, and 12 months later.
RESULTS: Treatment in all groups led to a statistically significant reduction in the severity of positive symptoms (p <0.001). Hallucinations proved more susceptible to therapy (p <0.001), while persistent delusions showed greater treatment resistance. Significantly more patients in the PP1M and PP3M groups had completed the entire program (n=24; 48.0%, and n=30; 58.8%, respectively) compared to the OP group (n=11; 20.4%). The PP3M group demonstrated the highest treatment adherence, with the largest number of patients completing the study, and a similar rate of exacerbations or inadequate efficacy compared to the other groups.
CONCLUSION: Treatment with different forms of paliperidone provides a roughly equal pace reduction in the severity of schizophrenia, including positive and negative symptoms. The PP3M group had better adherence and the highest number of patients who fully completed the study.
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REVIEW
The Use of Melatoninergic Antidepressants for Stabilization of Remission in Depression Comorbid with Alcohol Abuse, Anxiety or Neuropsychiatric Disorders: A Systematic Review
Abstract
BACKGROUND: Depression is one of the most common mental disorders and is associated with a significant increase in the risk of mental and somatic comorbidities. The chronobiological theory of the pathogenesis of depression explains the relationship between the symptoms of depression and disturbance of circadian rhythm regulation. Disrupted circadian rhythms are also observed in other disorders such as alcohol use disorder, anxiety disorders, epilepsy, and Parkinson’s disease. Therefore, there is a growing interest in the use of medications with a melatoninergic mechanism of action in the treatment of depression comorbid with the aforementioned disorders.
AIM: This review aims to systematically examine the evidence for the use of melatoninergic antidepressants (agomelatine and fluvoxamine) in the treatment of depression comorbid with alcohol abuse, anxiety disorders (including phobic anxiety, panic, and generalized anxiety disorders), or neuropsychiatric disorders (such as epilepsy and Parkinson’s disease).
METHODS: This systematic review included experimental studies, systematic reviews, and meta-analyses published in English and Russian, which examined the use of fluvoxamine and agomelatine in adult patients with recurrent depressive disorder (ICD-10) or major depressive disorder (DSM-5) comorbid with alcohol abuse, anxiety or neuropsychiatric disorders. The search was conducted in the PubMed, Cochrane Library and eLIBRARY scientific databases. The quality of the selected studies was assessed using the Cochrane Risk of Bias tool, which is used to evaluate the risk of systematic errors in clinical studies. The results were presented as a narrative synthesis and grouped by the comorbidities evaluated.
RESULTS: A total of 20 articles were reviewed (with a pooled sample size of n=1,833 participants). The results suggest that melatoninergic antidepressants might help in reducing depressive and anxiety symptoms, improve sleep, decrease alcohol cravings, and alleviate the severity of motor symptoms in Parkinson’s disease. Moreover, the use of pharmacogenetic testing to select the medication and dosage may enhance its therapeutic effectiveness.
CONCLUSION: The review demonstrates a significant lack of clinical data and guidelines on the use of melatoninergic medications for the treatment of depression comorbid with other disorders. In this regard, it is currently difficult to draw a definitive conclusion regarding the efficacy and safety of agomelatine and fluvoxamine in the treatment of these comorbidities. Available studies suggest an improvement in the clinical manifestations of the comorbidities. Future research directions might include the development and implementation of double-blind, randomized clinical trials to study the use of melatoninergic medications in patients with depression comorbid with other disorders.
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Comparison of Immune and Systemic Inflammation Parameters in Patients with a Depressive Episode in Bipolar Disorder and Major Depressive Disorder: A Scoping Review
Abstract
BACKGROUND: Many studies have aimed to investigate and compare immune system and systemic inflammation parameters in patients with bipolar disorder (BD) and major depressive disorder (MDD) suffering from a depressive episode. However, no systematic review of the results has been conducted so far.
AIM: The aim of this study was to conduct a scoping review of research studies comparing immune and systemic inflammation parameters in patients with BD and MDD during a depressive episode.
METHODS: The search for studies was conducted in the Medline and eLIBRARY databases for the period from January 1994 to December 2022. Open-access articles written in English and Russian were selected. The review included original studies that compared groups of patients with BD and MDD (diagnosed based on the DSM-IV, DSM-5, or ICD-10 criterion) by immune and systemic inflammation parameters (such as the counts, ratio, and functions of blood cells, erythrocyte sedimentation rate, concentrations of immunoglobulins, cytokines, acute phase proteins, complement components, and autoantibodies).
RESULTS: The review included 24 studies. Current depressive episodes in patients with BD were associated with higher concentrations of chemokines (C-C motif chemokine ligand 3 (CCL3), CCL4, CCL5, CCL11), platelet-derived growth factor B, and interleukin 9 (IL-9) (two studies in each case), whereas patients with MDD tended to have higher concentrations of soluble tumor necrosis factor receptor 1 and immunoglobulin G to oxidized low-density lipoproteins (two studies each). Patients with BD and MDD had comparable concentrations of IL-8 (five studies); IL-2 and IL-10 (four studies each); IL-13 and gamma interferon (three studies each); IL-17, IL-1Rα, the vascular endothelial growth factor, as well as white blood cells, monocyte, and platelet counts (two studies each). Contradictory results were obtained for the levels of tumor necrosis factor-α (the concentrations did not differ in five studies, were elevated in BD patients in five studies, were elevated in MDD patients in two studies), IL-6 (the concentrations did not differ in eight studies and were elevated in BD patients in four studies), C-reactive protein (the concentrations did not differ in six studies, were elevated in BD patients in two studies), IL-4 (the concentrations did not differ in three studies and were elevated in MDD patients in two studies), IL-1β and the neutrophil count (the levels did not differ in one study each and were elevated in BD patients in two studies). Several studies have demonstrated an association between immune and systemic inflammation parameters and the severity of depressive and anxiety symptoms, melancholic depression, age of mood disorder onset, body mass index, and imipramine equivalent.
CONCLUSION: Some immune and systemic inflammation parameters are associated with a current depressive episode in patients with MDD or BD. These parameters may be considered as potential biomarkers for a differential diagnosis of these disorders.
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The Mental Health of Refugees and Forcibly Displaced People: A Narrative Review
Abstract
BACKGROUND: One of the pressing global issues today is the matter of refugees and forcibly displaced people migration. Refugee or forcibly displaced status has a significant impact on a person's mental health, with a high risk of developing depression, anxiety, post-traumatic stress disorder and psychotic disorders.
AIM: To conduct a literature review and evaluate the mental health status of refugees and forcibly displaced people due to military action
METHODS: The search of literature was conducted without any restrictions on the publication date, with a focus on articles from the past two decades. The search was conducted in the Google Scholar and PubMed databases using the following keywords and phrases: “migration”, “migrants”, “refugees”, “forcibly displaced people”, “mental health”, “mental disorder”, “psychiatric disorders”. This analysis included studies that discussed and evaluated the social, psychological, and clinical aspects of migration. The review included original research and meta-analyses published in English, Russian, and Spanish. Descriptive analysis was applied to summarize the results.
RESULTS: The literature review showed that global migration levels have reached a high point, and this trend continues due to the existing geopolitical conditions. Even limited and difficult-to-compare epidemiological data demonstrate that more than a quarter of migrants suffer from mental disorders. These primarily include depression, anxiety, and post-traumatic stress disorders. Apart from creating and exacerbating problems for the refugees and forcibly displaced people themselves, they also pose serious challenges to the social services and healthcare systems of refugee-hosting countries. The literature review demonstrated that forced displacement plays a role in the development of mental disorders, and also emphasizes the significance of several associated factors.
CONCLUSION: This review emphasizes the urgent need for standardizing screening methods for refugees and forcibly displaced people, creating unified approaches to diagnostic evaluation, as well as specialized training for mental health professionals. Large-scale programs are needed to support and implement sustainable global mental health measures in the countries affected by hostilities.
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CASE REPORT
Integrating Rational Emotive Behavior Therapy, Compassion-Focused Therapy with Cognitive Retraining in Traumatic Brain Injury: A Case Report
Abstract
BACKGROUND: This case report presents a novel approach to treating Traumatic Brain Injury (TBI) by integrating Rational Emotive Behavior Therapy (REBT), Compassion-Focused Therapy (CFT), and Cognitive Retraining (CR). It contributes to the literature by demonstrating the effectiveness of a comprehensive psychotherapeutic approach in managing complex TBI sequelae, particularly in the Indian context where such interventions are underrepresented.
CASE REPORT: A 34-year-old Indian female presented signs of emotional dysfunction, cognitive impairment, social maladaptation, shamefulness, and self-deprecation following a TBI sustained 10 years prior. A mental status examination and psychological assessments revealed cognitive deficits, emotional instability, and irrational beliefs, all related to her injury and recovery. The treatment plan integrated REBT, to address the irrational beliefs; CFT, to manage the sense of shame and the insistence to self-criticize; and CR, to improve cognitive functions. This approach was tailored to the patient’s cognitive limitations and cultural context. Interventions included challenging irrational beliefs, self-compassion imagery, and cognitive exercises adapted to her specific deficits. Outcomes were measured using the Subjective Units of Distress (SUD) scale and clinical observations. The patient showed improvements in emotional regulation, cognitive functioning, and overall quality of life, as evidenced by reduced subjective distress (SUD down from 90 to 58) and enhanced daily functioning.
CONCLUSION: This case demonstrates that an integrated psychotherapeutic approach combining REBT, CFT, and CR can effectively address the complex psychological and cognitive challenges of TBI patients. Tailoring interventions towards patient cognitive limitations and cultural context is crucial for a successful outcome. The case highlights the importance of incorporating diverse therapeutic modalities in TBI management, promoting a more holistic approach to recovery and enhancing the quality of life of TBI survivors.
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